ESTUDIO WHI, REVISTA DE MENOPAUSIA, SALUD, REVISTAS MÉDICAS. Actualidad Inmediata Debido a la importancia de esta investigación y al impacto en. WHI. Progestin. Estrogen. Tibolone. Cardiovascular disease. Tromboembolic disease . Boletín de la Asociación Española para el Estudio de la Menopausia, . Los trastornos de la menopausia pueden ser evitados y combatidos Sin embargo, recientes estudios, como el estudio WHI, han puesto en duda los beneficios.

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Diabetes Care, 25pp. Controlled Clin Trials ; Menopausal estrogen and estrogen-progestin replacement therapy and breast cancer risk. Clinical effects of a standardized soy extract in postmenopausal women: The Nurses’ Health Study and studies from Europe, where estradiol is the commonly prescribed form of estrogen, suggest that the estrogen at lower doses may confer similar benefit” [ 15 ] Luckily one has nowadays an ample choice of strategies and drugs hormonal and non-hormonal that enable a conscientious physician to do his best to restore the confidence of those women who have sought his help.

Dietary intake of phytoestrogens is associated with a favorable metabolic cardiovascular risk profile in postmenopausal US women: The Management of the Menopause. The authors raised two important questions that need attention.

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At present, in some European countries the indication for prevention of postmenopausal osteoporosis by HRT will be re-assessed according to public statements of drug licensing authorities.

The estrogen-alone data were published in and were summarized once again in two separate papers [4,5]: A review of the clinical effects of phytoestrogens. Ipriflavone Multicenter European Fracture Study. Primum, non nocereneither by excess nor by abstention, as well La primera es el papel potencial de los diferentes preparados hormonales versus los efectos cognitivos adversos relacionados por ej. Urinary excretion of phytoestrogens and risk of breast cancer among Chinese women in Shangai.


Third, the results of a crucial study should preferably be expressed in such a way that practitioners may setudio them for their practice to inform users.

Phytochemistry, 65pp. Amer J Clin Nutr, 78pp. The order of magnitude of the relative risks is impressive. Cancer Causes Control, 13pp.

Isoflavonas y menopausia | Clínica e Investigación en Ginecología y Obstetricia

Breast cancer risk following long-term oestrogen and oestrogen-progestin replacement therapy. Beneficial effects of soy phytoestrogen intake in postmenopausal women with type 2 diabetes. Bone Miner Res, 17pp. This concept failed in this specific, large group of women estudlo.

Breast and uterine effects of soy isoflavones and conjugated estrogens in postmenopausal female monkeys. Efficacy of a soy rich diet in preventing postmenopausal osteoporosis.

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Annals de Medicina, 87pp. Hu FB, Grodstein F. The authors of these re-analyses of the HERS Study conclude that they did not identify any sub-groups of HERS participants in which postmenopausal treatment was clearly beneficial or harmful.


Maturitas, 42pp. The increased risk of breast cancer became apparent only after the fourth year of treatment. This was the case with the WHI, a study aimed at the primary prevention of cardiovascular diseases in healthy postmenopausal women. There is no reason to avoid postmenopause hormone medication when indicated and not contra-indicated.


The WHI is an important study. Is there a menopausal medicine? Which clinical studies provide the best evidence?

Clin Invest Gin Obst, 30pp. JAMA,pp. For instance, in the HERS Study it is difficult to explain why hormone therapy would increase the risk of coronary events in women with less than 3 live births and in those living alone! Mwnopausia provided an unprecedented chance to examine the hypothesis that HT may have protective effects on cognition in younger postmenopausal women aged 50—54 years.

N Engl J Med,pp. Cancer Epidemiol Biom Prev, 11pp. Menlpausia the protocol of the study it is mentioned that women had to have a base line mammography [ 5 ]. Recent diet and breast cancer risk: It must be emphasized that the WHI report stresses that the results do not necessarily apply to lower dosages of those drugs, to other formulations of oral estrogen and progestin or to estrogens and progestins administered through the transdermal route [ 1 ].

Am J Clin Nutr, 72pp. Estrogen plus progestin and the risk of coronary heart disease. The observed lower event rate in smokers compared with non-smokers in the hormone group is intriguing.

Menopause, 7pp. Int J Cancer,pp.